【文题】Glutathione S-transferase M1 polymorphism may contribute to schizophrenia in the Korean population

【杂志】Psychiatr Genet. 2004 Sep;14(3):147-50.

【作者】Pae CU, Yu HS, Kim JJ, Kim W, Lee CU, Lee SJ, Jun TY, Lee C, Paik IH, Serretti A.

【单位】Department of Psychiatry, Kangnam St Mary's Hospital, The Catholic University of Korea College of Medicine, Banpo-Dong, Seocho-Gu, Seoul, Korea.

【文摘】The association between Glutathione S-Transferase M1 gene (GSTM1) polymorphism and schizophrenia was examined. One hundred and eleven in-patients with schizophrenia and 130 healthy controls were enrolled in this study. Genotyping was performed using a polymerase chain reaction-based method. The GSTM1 null genotype was significantly more frequent in the schizophrenia patients than in the controls (P=0.014, odds ratio=1.93, 95% confidence interval=1.115-3.351). On the other hand, the GSTM1 genotype variants were not associated with tardive dyskinesia or total abnormal involuntary movement scale scores.This study suggests that, at least in the Korean population, the GSTM1 polymorphism may confer susceptibility to the development of schizophrenia but not to tardive dyskinesia.

【翻译】本实验研究谷胱甘肽S-转移酶 M1 基因（GSTM1）多态性与精神分裂症的关系。111名精神分裂症病人和130个健康受试者参与本次实验。采用聚合酶链反应方法对基因型进行分析。结果表明精神分裂症病人GSTM1基因缺失明显高于正常对照组（P=0.014,不等比例为1.93，95%可信区间=1.115-3.351）。另外，GSTM1基因型改变与迟发性运动障碍或总的异常不随意运动评分无关。本实验表明，至少在韩国人群中，GSTM1基因多态性是精神分裂症而非迟发性运动障碍的易感因素。

转自  ziyu00