我是搞精神病学基础研究的，所以文献摘要的内容和临床应用不一致，不知道大家感不感兴趣？愿意和大家交流一下。

Neuregulin 1 and schizophrenia.

Stefansson H, Steinthorsdottir V, Thorgeirsson TE, Gulcher JR, Stefansson K.

deCODE Genetics, Sturlugata 8, IS-101 Reykjavik, Iceland. hreinn@decode.is

We discuss in this review the role of the neuregulin (NRG1) gene in schizophrenia. NRG1 contributes to the genetics of schizophrenia in both Icelandic and Scottish schizophrenia patients. NRG1 participates in glutamatergic signaling by regulating the N-methyl-D-aspartate (***A) receptor through the interaction of the NRG1 protein and its receptors. NRG1 plays a central role in neural development and is most likely involved in regulating synaptic plasticity, or how the brain responds or adapts to the environment. The discovery that defects in NRG1 signaling may be involved in some cases of schizophrenia, not only implicates NRG1, but suggests that its biological pathway, active both at developing and mature synapses, is worth inspecting further in a search for other schizophrenia genes possibly in epistasis with NRG1.

neuregulin 1 和精神分裂症
在这篇综述里我们讨论neuregulin（NRG1）基因在精神分裂症中的作用。在冰岛和苏格兰的人群中NRG1基因对于其精神分裂症的遗传具有作用。NRG1与其受体作用可以调节N-甲基-D-天门冬氨酸受体，进而参与到谷氨酸信号通路中去。NRG1在中枢发育中有重要作用，并且可能参与突触可塑性的过程，或者说参与脑对环境的反应与适应过程。已经有发现NRG1信号的缺陷可能在某些精神分裂症的患者中发生，这提示NRG1的信号通路在发育中的和成熟的突触中都是有活动的，值得进一步寻找可能存在的NRG1的上位显性基因。

转自  zhangdi